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MIT News
Cell-preservation technique could make CAR-T cell therapy more accessible
Researchers at MIT have introduced a groundbreaking preservation technique for CAR-T cells, which are essential in treating certain blood cancers. Current practices involve cryoprotectants like DMSO, which complicate the process and require removal prior to treatment, limiting access to this therapeutic option. The new method utilizes nontoxic antifreeze sugars to protect cells during freezing, potentially expanding the reach of CAR-T therapies to more hospitals. This innovation promises to increase the viability of the cells post-thaw, enhancing treatment effectiveness for conditions like lymphoma and glioblastoma.
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Published 19 Aug 2026, 04:15 UTC5 min read
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Summary
TL;DR
- MIT developed a new technique to preserve CAR-T cells using nontoxic sugars.
- This method reduces reliance on harmful cryoprotectants like DMSO.
- Improved cell survival rates during freezing and thawing were observed.
- The approach aims to make CAR-T therapy accessible for more hospitals.
- Research showed higher efficacy in treating cancer in mouse models.
Interesting facts
- The technique is inspired by antifreeze mechanisms found in Arctic organisms.
- Electroporation was used to introduce sugars into the CAR-T cells.
- Higher survival rates of CAR-T cells preserved with sugars compared to DMSO.